Sildenafil under the name Viagra is used to treat erectile dysfunction (impotence) in men. Different brands may not work the same way. Properly discard this product when it is expired or no longer needed. Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. The amount of medicine that you take depends on the strength of the medicine. To view formulary information first create a list of plans. Delay initiation of treatment with any CYP3A4 substrates for at least 7 days following discontinuation of conivaptan. This medicine is available only with your doctor's prescription. Serious - Use Alternative (1)St John's Wort will decrease the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. zafirlukast will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor (1)cyclophosphamide will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Potent CYP3A4 inducers are expected to cause substantial decreases in sildenafil plasma levels. Pulmonary veno-occlusive disease or PVOD (a type of lung disease)Use with caution. Avoid or Use Alternate Drug. amobarbital will decrease the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. lonafarnib will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Kidney360. Viagra is an effective drug for treating male erectile dysfunction, but it targets sexual performance, not sexual arousal. Minor (1)macitentan increases levels of sildenafil by unspecified interaction mechanism. Use Caution/Monitor. Monitor blood pressure response to sildenafil in patients receiving concurrent blood pressure lowering therapy. After discontinuation of a strong CYP3A inhibitor, resume crizotinib dose used prior to initiating the strong CYP3A4 inhibitor. Monitor Closely (1)bisoprolol increases effects of sildenafil by additive vasodilation. Monitor Closely (1)butalbital will decrease the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use only the brand of this medicine that your doctor prescribed. Sildenafil is also FDA approved under the brand name Viagra for the treatment of erectile dysfunction. Monitor Closely (1)erythromycin stearate will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Another brand of sildenafil is Revatio, which is used to treat pulmonary arterial hypertension and improve exercise capacity in men and women. Avoid use of strong CYP3A4 inhibitors. Avoid or substitute another drug for these medications when possible. Use Caution/Monitor. Patients who take Liqrev should not take Viagra or any other PDE-5 inhibitors. Modify Therapy/Monitor Closely. Do not store in the bathroom. Injections are dosed at 2.5 mg or 10 mg three times a day, 4 to 6 hours apart, as an . Erythromycin (Systemic): May increase the serum concentration of Sildenafil. dronedarone will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. idelalisib will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. If you take sildenafil for pulmonary arterial hypertension, do not take Viagra or other PDE5 inhibitors, including tadalafil (Cialis) or vardenafil (Levitra). It works by dilating blood vessels and increasing blood flow to certain areas of the body. CYP3A4 substrates may require dosage adjustment. Use Caution/Monitor. Avoid or Use Alternate Drug. fosphenytoin will decrease the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or substitute another drug for these medications when possible. isosorbide dinitrate, sildenafil. Monitor Closely (1)griseofulvin will decrease the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. When used for erectile dysfunction, consider reducing initial sildenafil dose of 25 mg in patients also taking a strong CYP3A4 inhibitor and monitor for sildenafil toxicities (eg, dyspepsia, headache, hypotension). Published In Use Caution/Monitor. Monitor blood pressure response to sildenafil in patients receiving concurrent blood pressure lowering therapy. Avoid or Use Alternate Drug. Serious - Use Alternative (1)phenytoin will decrease the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Use Caution/Monitor. Inititiation of weak CYP2C19 inhibitors may require decreased mavacamten dose. Use of nitroglycerin within a few days of PDE5 inhibitors is contraindicated. Your list will be saved and can be edited at any time. By clicking send, you acknowledge that you have permission to email the recipient with this information. Use Caution/Monitor. Avoid or Use Alternate Drug. Potent CYP3A4 inducers are expected to cause substantial decreases in sildenafil plasma levels. Avoid or Use Alternate Drug. Avoid coadministration of sensitive CYP3A4 substrates with ivosidenib or replace with alternative therapies. Monitor Closely (1)lorlatinib will decrease the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Coadministration with PDE-5 inhibitors may result in an increase in PDE-5 inhibitor-associated adverse reactions (eg, hypotension, syncope, visual disturbances and priapism). Use Caution/Monitor. It is used to treat erectile dysfunction (ED) in men 18 years and . Either increases effects of the other by pharmacodynamic synergism. Monitor Closely (1)deferasirox will decrease the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvcmV2YXRpby12aWFncmEtc2lsZGVuYWZpbC0zNDI4MzQ=, View explanations for tiers and sildenafil also comes as 20-mg . Monitor Closely (1)idelalisib will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. ceritinib will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)letermovir increases levels of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. sildenafil, comes in 20-mg tablets. When used for erectile dysfunction, consider reducing initial sildenafil dose of 25 mg in patients also taking a strong CYP3A4 inhibitor and monitor for sildenafil toxicities (eg, dyspepsia, headache, hypotension). Many people using this medication do not have serious side effects.Sexual activity may put extra strain on your heart, especially if you have heart problems. Aim: To assess the efficacy and safety of sildenafil vs placebo according to age subgroups (<65, 65-74, and 75 years) in 11,364 men with erectile dysfunction using pooled data from 48 randomized, double-blinded . Risk of hypotension; separate sildenafil >25mg from alpha blocker by 4hr. atenolol increases effects of sildenafil by additive vasodilation. Potentially fatal hypotension. Use Caution/Monitor. Minor/Significance Unknown. nitroglycerin translingual, sildenafil. Most ED cases can be attributed to organic and/or psychological factors. Minor (1)larotrectinib will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. To date, the Company has identified men's wellness telemedicine services and products as a growing sector and especially related to the area of erectile dysfunction (ED). Avoid or Use Alternate Drug. cimetidine will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. It's important to note that erectile dysfunction can happen from time to time, even in young people . Use Caution/Monitor. Mechanism: additive vasodilation. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Risk of hypotension; separate sildenafil >25mg from alpha blocker by 4hr. Potentially fatal hypotension. Use Caution/Monitor. FARMVILLE, N.C., June 21, 2023 /PRNewswire/ -- CMP Pharma, Inc. announced today that Liqrev (Sildenafil) Oral Suspension, 10 mg/mL, the first and only FDA-approved ready-made oral liquid of . Use Caution/Monitor. Use Caution/Monitor. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Sildenafil has systemic vasodilatory properties and may further lower blood pressure in patients taking antihypertensive medications. Never use combination with chronic sildenafil for PAH. Avoid or Use Alternate Drug. Sildenafil belongs to a group of medicines called phosphodiesterase 5 (PDE5) inhibitors. Avoid concurrent or sequential use to decrease risk for ototoxicity. sildenafil, vericiguat. Monitor Closely (1)indinavir will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Adults 65 years of age and older25 mg as a single dose no more than once a day, 1 hour before sexual intercourse. Mechanism: additive vasodilation. Use Caution/Monitor. Avoid coadministration with sensitive CYP3A4 substrates with a narrow therapeutic index. Use Caution/Monitor. PRECAUTIONS: Before taking sildenafil, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. Use Caution/Monitor. Contraindicated (1)cobicistat will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. enzalutamide will decrease the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Potentially fatal hypotension. phenytoin will decrease the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Serious - Use Alternative (1)ritonavir will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Possible additive vasorelaxation, leading to low blood pressure. Jiang Shulan smiled mischievously . Monitor CYP3A substrates if coadministered. Edmonston D, Sparks M, Rajagopal S, Wolf M. Sildenafil and Kidney Function in Heart Failure with Preserved Ejection Fraction. Minor/Significance Unknown. Use Caution/Monitor. If any of these effects last or get worse, tell your doctor or pharmacist promptly.To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Sildenafil has systemic vasodilatory properties and may further lower blood pressure in patients taking antihypertensive medications. Sildenafil has systemic vasodilatory properties and may further lower blood pressure in patients taking antihypertensive medications. Avoid coadministration with sensitive CYP3A4 substrates with a narrow therapeutic index. erythromycin base will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Serious - Use Alternative (1)mifepristone will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Potent CYP3A4 inducers are expected to cause substantial decreases in sildenafil plasma levels. grapefruit will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Serious - Use Alternative (1)ketoconazole will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. posaconazole will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor (1)acetazolamide will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor blood pressure response to sildenafil in patients receiving concurrent blood pressure lowering therapy. Coadministration of vericiguat with PDE-5 inhibitors may result in additive hypotensive effects. Sildenafil has systemic vasodilatory properties and may further lower blood pressure in patients taking antihypertensive medications. Avoid or Use Alternate Drug. Serious - Use Alternative (1)voxelotor will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)butabarbital will decrease the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Coadministration may increase risk for adverse effects of CYP3A4 substrates. Avoid or Use Alternate Drug. It continues to work for up to 4 hours, although its action is usually less after 2 hours. eslicarbazepine acetate will decrease the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. macitentan increases levels of sildenafil by unspecified interaction mechanism. maraviroc, sildenafil. If used concomitantly, monitor for toxicities. This means you can have sex at any time, rather than needing to take a pill from time to time as needed like other ED brands. Iloperidone is a time-dependent CYP3A inhibitor and may lead to increased plasma levels of drugs predominantly eliminated by CYP3A4. Read and follow these instructions carefully before you start using sildenafil and each time you get a refill of your medicine. Avoid or Use Alternate Drug. Monitor CYP3A substrates if coadministered. Use Caution/Monitor. Avoid or Use Alternate Drug. Potent CYP3A4 inducers are expected to cause substantial decreases in sildenafil plasma levels. Potent CYP3A4 inducers are expected to cause substantial decreases in sildenafil plasma levels. Potent CYP3A4 inducers are expected to cause substantial decreases in sildenafil plasma levels. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Monitor Closely (1)enzalutamide will decrease the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Iloperidone is a time-dependent CYP3A inhibitor and may lead to increased plasma levels of drugs predominantly eliminated by CYP3A4.
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