Data are expressed as the mean SD (n = 6 rats/group). Here are a few common ones we see from very unique perspectives. It is further proved by the histological changes. Neurosurg. Yan Ji, L.Ac., M.S., M.D. Services that we offer include: Share on Facebook Share on Twitter Share on Linked In Share by Email, Acupuncture.Com - Home of Traditional Chinese Medicine, Monday - Friday 8AM5:30PM Saturday 9AM12PM Sunday Closed, https://www.youtube.com/watch?v=Jbdr2pQ77Jg. List of acupuncture points. (AF) Immunohistochemistry results of RIPK1, RIPK3, and MLKL in spinal cord of rats in each group. aware that email is not a secure means of communication and spam filters may prevent your email from reaching the health Arrows with different colors means different structure and pathological changes, listed with the image. She also learned more from her grandfather . Sweden made LKB-III ultra-thin slicing machine was used to section with the thickness of about 500A. Specific inhibition of RIPK1 kinase activity is found to block necroptosis and inflammation (Degterev et al., 2008). Dr. Ji offers traditional Chinese acupuncture, Chinese herbs, electroacupuncture, cupping therapy, Tui Na (acupressure), Gua Sha; specializes in pain management, infertility, anxiety, insomnia, allergy, Bell's palsy, ED, BPH, diabetes, weight loss, women health, wellness, etc. These data make the case that Jia-Ji electro-acupuncture treatment may improve locomotor function by promoting autophagy flux and inhibiting necroptosis. with appreciation for all of the special attention and care. Thus, the interaction of lysosomal/autophagy and necroptosis may play a key role in improving neuronal survival and functional outcomes after SCI injury. In rat model of SCI, we observed that there was a significant improvement on motor function after EA treatment compared to Model group at 3 and 7 days time points (P < 0.01). Ji Acupuncture & Oriental Medicine Clinic is located in Greenwood Village, Colorado (just south of Denver). Epidemiol. doi: 10.1016/s0079-6123(09)17508-8, Basso, D. M., Beattie, M. S., and Bresnahan, J. C. (1995). HE staining was performed for histopathological examination. I specialize in acupuncture and chiropractic for pain management, pregnancy, fitness, rehabilitation, and much more, A 5th generation licensed acupuncturist and herbalist trained in China. Greenwood Village, CO 80111. So it can not only decrease the input path, but at the same times it can also increase the output path by adjusting the built-in metabolism system in our body, and there is no pain but just a little bit feeling like a little bit sore, numbness or tingling. In this study, the effects of EA on improvement of lower limb function in rat modal would be investigated to explore its mechanism of autophagy flux and necroptosis regulated by lysosomal dysfunction after SCI, and to provide a potential effective therapy for SCI. Keep Smiling. Ji is a Master of Science in Oriental Medicine and he is certified as a licensed acupuncturist by both the Acupuncture Board of California. HT 1: ji quan / Highest Spring. Besides, the lysosome inhibitor CQ partially eliminated the therapeutic effect of EA on promoting autophagy flux and inhibiting necroptosis. Compared with the EA group, RIPK1, RIPK3, and MLKL protein expression in the EA + CQ group increased significantly at each time points after injection of inhibitor CQ (RIPK1: P < 0.01, P < 0.05; RIPK3: P < 0.05, P < 0.01; MLKL: P < 0.01, Figure 9). At the time points of 3 and 7 days, the appearance and structure of the spinal cord tissues in the Sham group were normal, while the hematoma in the spinal cord attack area in the Model group was obvious. It is not easy to be overweight again. Services. And 3 and 7 days subgroups were focus of subsequent studies. We had been trying for 6 years to have a baby and after trying acupuncture we had twin girls! Necroptosis inhibitor necrostatin-1 promotes cell protection and physiological function in traumatic spinal cord injury. In future studies, we will explore the mechanism of Jia-Ji electro-acupuncture on lysosomal function and whether it could induce neuron regeneration and remodeling through this pathway. The lesions that had been red and inflamed, turned pitch black. 2 reviews of Hui Ji Acupuncture Clinic "I experienced dizziness for years after surviving cancer. Dr. Ji obtained his M.D. So 3 and 7 days time points were selected as time points in the following study. EA could promote bleeding absorption, reduce edema and protect spinal cord. Figure 7. Ji Acupuncture & Oriental Medicine Clinic is located in Greenwood Village, Colorado (just south of Denver). Loading sample for electrophoresis and then transferred the protein to the PVDF membrane. My whole family has benefited from the talent and experience at Shie Ji. (2016). I am so glad I did. I've been to 10+ acupuncture clinics and she is by far the best. The needles may be manipulated manually or stimulated with small electrical currents (electroacupuncture). The data were presented as mean standard deviation ( SD). With Micro Plus type pulse electro-acupuncture (BioMedical Life Systems, Inc., Vista, CA, United States), the positive pole was connected to the upper needle handle, and the negative pole to the lower needle body on the same side. Mol. The expression of LC3-II was all higher than that in the Model group at each time point (P < 0.01) after EA treatment, while the protein expression levels of P62, RIPK1, RIPK3, and MLKL were all lower than that in the Model group (P < 0.05), indicating that EA could promote autophagy flux and inhibit necroptosis at the same time. Prog. Qiaoli Leisskill and intuitiveness has helped me become healthier. GF collected, analyzed data, and wrote the manuscript. I have been a student of mind/body medicine for most of my adult life, and have had remarkable results with acupuncture. counsellor. Autophagy 10, 22082222. Doctors who also practice acupuncture are called medical acupuncturists. Rats in Sham, Model, EA, and EA + CQ groups were deeply anesthetized with 10% chloral hydrate and executed, then the injury section of spinal cord tissue were fixed in 4% paraformaldehyde. You are a very special person. LQ performed statistics. Let us help you get to the source of your problems and restore balance and harmony. Cell Death Dis. You should check with your health insurance whether the particular doctor is in network or not. Acupuncture and electroacupuncture (EA) as complementary and alternative medicine have been accepted worldwide mainly for the treatment of acute and chronic pain. Mol. The animal study was reviewed and approved by the International Council for Laboratory Animal Science (ICLAS) and Animal Care and Use Committee of China. Highly recommend seeing Dr. Lei and Dr. Yi. Rapid diagnosis and neuroprotective interventions at the stage of acute injury are therefore critical, and these treatments have the potential to significantly improve subsequent long-term functional recovery. Since moving here, my son has developed reactive airway disease that is aggravated. ##P < 0.01, vs. Sham; *P < 0.05, **P < 0.01, vs. Model; &P < 0.05, &&P < 0.01, vs. EA. While after EA treatment, several neurons could be seen, the damage tissue and inflammation factors reduce. Adverse reactions associated with conventional medicines and surgical interventions have forced Americans to look for alternative forms of treatment that are safe and effective. After EA treatment, the expression level of LC3-II protein increased, which was statistically significant compared with the Model group at the time points of 3 and 7 days (P < 0.01). You can call their office to find out more about same day appointments. The annual incidence of SCI in the United States is about 17,000 new cases per year (National Spinal Cord Injury Statistical Center, 2016). Our commitment to staying updated in the profession enables us to provide the best comprehensive treatment possible. professional. We help treat and manage a variety of conditions including: All content Copyright Ji Scott Acupunture. We specialize in pain management, infertility, GI disorder, cancer care, depression, and stroke rehabilitation and much more, A 6th generation acupuncturist and chiropractor with training in China. The World Health Organization recognizes its efficacy in treating 43 common disorders and illnesses. The SCI model was then produced using a NYU Impactor M-III strike (a 10 g pouching rod of 2.5 mm diameter with drop of 50 mm and damage of 50 gcm) at the T10 segment to create relatively serious injury (Verma et al., 2019). Theyre a great team and you can feel that they truely care. Schedule a consultation today to learn more about Denver's holistic therapy for both men and women that can lead to improved health. In our results, RIPK1, RIPK3, and MLKL were mainly expressed in the cytoplasm of neurons and glial cells, but also shown in the intercellular substance, possibly because necroptosis factors in the cytoplasm were released into the intercellular after cell rupture. Spinal cord injury (SCI) may cause structural and functional impairment of the spinal cord, leading to sensory, motor or autonomic nerve dysfunction, and ultimately affecting the patients physical, psychological, and social abilities (Singh et al., 2014). Take exit 199 from I-25, make a right turn onto E. Belleview Ave, then turn right again onto DTC PKWY (first signal). doi: 10.1002/ca.22432, National Spinal Cord Injury Statistical Center (2016). RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS. Due to a repressed immune system, my body became covered with open sores that two specialists and my family practitioner were unable to help over a period of 3 months. The name of the clinic, Kun Ji Tang (Kun Ji Acupuncture) , was chosen by Sze's mentor, Dr. Kezhen Zhang . Dr. Chiu understood its cause, however, and finally I am no longer suffering from dizziness. 6:e1582. These results indicate that the expression of LC3-II protein increases and autophagy increases after SCI, which may be caused by the blockage of autophagy flux. 70, 294304. After treatment, the average optical density values of RIPK1, RIPK3, and MLKL in the EA group were lower than those in the Model group at each time point (P < 0.05), indicating the inhibitory effect of EA on necroptosis. According to Traditional Chinese Medicine (TCM), diabetes is caused by an imbalance of the cyclical flow of Qi within the meridians and organ systems. Dong Ji accepts various types of health insurance, but individual coverage may be variable. In Sham group, the anterior horn motor neurons were orderly arranged without significant reduction, deep blue staining. It has been previously demonstrated that autophagy flux is inhibited after SCI in the mouse model, with obvious accumulation of autophagy markers LC3-II and autophagy substrate P62/SQSTM1 in ventral motor neurons (Liu et al., 2015b). (A) Spinal cord tissue appearance. Ive been going to see these incredible folks for 4 years now and have gotten incredible results for my prostate cancer. Expose the T9-11 spinous processes, and resect the T10 lamina to create a gap around vertebral arch plate. Recent medical treatments attempt to reduce secondary damage and protect neurons that survive primary damage (Kwon et al., 2004). Electron microscopy was used to observe the structure changes of spinal cord tissue after injury. Impaired autophagy flux is associated with neuronal cell death after traumatic brain injury. Besides, the increased expression of LC3 and reduced expression of P62 after treatment compared with Model group, confirmed that Jia-Ji electro-acupuncture could enhance the autophagy flux. He is now a licensed acupuncturist and herbalist in both Colorado and California. The acupuncture treatment can promote the ovulation to achieve pregnancy. New patients are welcome. Time and time again, QiaoliLei has been there for me. More active lysosomes appeared after EA treatment, indicating Jia-Ji EA may stimulate lysosome function. 2019:2371084. doi: 10.1155/2019/2371084, Yoshii, S. R., and Mizushima, N. (2017). Of course, Chinese doctors have known of the benefits of TCM in the treatment of infertility long before it was ever studied in the West, with the first known publications on infertility appearing several hundred years ago. by environmental allergies. The autophagosome can be used as a basis to assemble necrotic complexes (Goodall et al., 2016). We are most fortunate to have such a gifted healer in our community. The number of motor neuron could increase after EA treatment. Hu, J., Han, H., Cao, P., Yu, W., Yang, C., Gao, Y., et al. Both doctors take their individual time to work with you and your special needs. at different time points. 24, 905918. J. It is estimated that endorphins are 200 times more potent than morphines. Contact. I will be back for my back issues now. of secondary infertility and 5 months of unsuccessful traditional fertility treatments. 2473 Merrick Road Bellmore, NY 11710 Call Yan Yan Yu (646) 647-3127 Nearby Areas Additional Location Whitestone Physical Therapy of Queens, P.C. (China), Chinese acupuncture specialist and herbalist, is an experienced expert in Traditional Chinese Medicine (TCM). Res. Cell Biol. After injection of inhibitor CQ, the expression of P62 protein in the EA + CQ group was higher than that in the EA group at each time point (P < 0.01). But, it helps and did so immediately. (2017). This study suggests that Jia-Ji EA treatment may promote the recovery of motor function through the mechanism of accelerating autophagy flux and alleviating necroptosis. Our, Common Questions About Acupuncture & Chinese Medicine, According to the recent scientific researches, the scientists find that the acupuncture can stimulate the hypothalamus-pituitary gland of the human body to create some specific chemicals, especially endorphins, the bodys natural pain-killing hormones. (China), Chinese acupuncture specialist and herbalist, is an experienced expert in Traditional Chinese Medicine (TCM). The association of palmitoylethanolamide with luteolin decreases autophagy in spinal cord injury. 23, 565577. doi: 10.1038/cddis.2014.527, Mortazavi, M. M., Verma, K., Harmon, O. Now her son is there practicing chiropractic medicine. Many studies supported lysosomal luminal alkalinizer chloroquine (CQ) as an inhibitor of autophagy flux in rats with SCI (Hu et al., 2017; Zhang et al., 2017). FAQ. Histological change of injured spinal cord tissue was alleviated after treatment, observed by hematoxylin-eosin and Nissl staining. A., Griessenauer, C. J., Adeeb, N., Theodore, N., et al. Due to recent studies, we now know that acupuncture affects the pituitary gland and acts on the sympathetic nervous system to reduce stress and regulate hormones. (B) Expression of RIPK3 protein in each group (RIPK3/-actin). My body always feels so much more healthy and whole after a session. I consider QiaoLi Lei a gift from God, and I feel blessed to know her and have her help. ##P < 0.01, vs. Sham; **P < 0.01, vs. Model; &P < 0.05, vs. EA. Massachusetts General Hospital, Harvard Medical School, United States. (2016). Evid. (2014). in 1985 from the Medical College of Qingdao University in China. PCR reaction solution was as follows: TBGreen Premix Ex Taql (Tli RNaseH Plus) (2 ): 10 l, PCR Forward Primer(10 M): 0.8 l, PCR Reverse Primer (10 M): 0.8 l, RT reaction solution (cDNA): 2 l, sterilized water: 6.4 l, Total: 20 l. The mRNA and protein expression levels of RIPK1, RIPK3 and MLKL were decreased in EA group. Effects of EA on the expression of necroptosis markers. Pain 32, 1221. The acupuncture therapy works by stimulating of specific points located on the surface of the skin to adjust the metabolism system. Dr. Ji offers traditional Chinese acupuncture, Chinese herbs, electroacupuncture, cupping therapy, Tui Na (acupressure), Gua Sha; specializes in pain management, infertility, anxiety, insomnia, allergy, Bells palsy, ED, BPH, diabetes, weight loss, women health, wellness, etc. Model group underwent T9-T11 SCI. The mechanism of electroacupuncture for treating spinal cord injury rats by mediating Rho/Rho-associated kinase signaling pathway. J. Spinal Cord Med. **P < 0.01, vs. EA group. Allens method was made by NYU Impactor M-III equipment to create the SCI rats model. These results indicated that CQ partially eliminated the effect of EA on promoting autophagy flux and inhibiting necrotizing apoptosis. Eur. In May 2023, Frontiers adopted a new reporting platform to be Counter 5 compliant, in line with industry standards. The mean optical density values of spinal cord tissues RIPK1, RIPK3, and MLKL in the Model group were significantly higher than those in the Sham group at 3 and 7 days after surgery (P < 0.01). JI Acupuncture Clinic 3 reviews Claimed Acupuncture Edit Closed 10:00 AM - 6:00 PM Hours updated over 3 months ago Write a review Add photo Photos & videos See all 9 photos Add photo About the Business We specialize in acupuncture treatments. Location & Hours 509 S Euclid St Anaheim, CA 92802 Get directions Edit business info Amenities and More 4, 451464. 303-337-2866. 28, 2736. (A) Expression of RIPK1 protein in each group (RIPK1/-actin). All authors contributed to the article and approved the submitted version. 114, e1186e1191. Front. Our miracle was born in January 2022 and he is so healthy! Previous studies have proved that the application of EA in the treatment of SCI is beneficial to the neurological and functional recovery of SCI (Ding et al., 2011; Huang et al., 2011). trained in China. Take exit 199 from I-25, make a left turn onto E. Belleview Ave, then turn right onto DTC PKWY (first signal). Copyright Acupuncture & Oriental Medicine | 5300 DTC Pkwy Suite 330, Greenwood Village, CO 80111, Denver Acupuncture - Specialists In Chinese Medicine. Besides, the expression peak of LC3 and P62 at 3 day was in accordance with that of necroptosis factors. You can request appointment via HealthSoul or contact their office. What Specialties Are Available With Ji Acupuncture? After blocking for 1 h, the PVDF membrane was incubated with the primary antibody at 4C overnight, as shown below: LC3B (1:2,000, Rabbit polyclonal antibody, United States Proteintech), P62 (1:1,000, Rabbit polyclonal antibody, United States Proteintech), RIPK1 (1:1,000, RIPK1 Rabbit PolyClonal antibody, United States Proteintech), RIPK3 (1:2,000, Rabbit polyclonal antibody, Beijing BIOSS), MLKL (1:1,000, Rabbit polyclonal antibody, United States Affinity), -actin (1:5,000, mouse monoclonal antibody, United States Proteintech).
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